BINOL-Al catalysed asymmetric cyclization and amplification: preparation of optically active menthol analogs.
نویسندگان
چکیده
We report a highly selective asymmetric ring-closing ene reaction catalysed by aluminum complexes with chiral BINOL. This reaction yields optically active 6-membered cyclized alcohols from unsaturated aldehydes, with good diastereo- and enantioselectivities. Asymmetric amplification of this reaction was investigated by varying the ee of the BINOL employed in the catalyst.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 13 20 شماره
صفحات -
تاریخ انتشار 2015